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The honest answer is that both very low and, in rare cases, very high B12 levels may be linked to shedding, but the strongest evidence points to deficiency as the real concern, not normal supplements

Drug-Disease Interactions Parkinsons (Levodopa): Pyridoxine may reduce levodopa effect

Choosing Between Vitamin B12 Injection and Oral Medications Deciding between injections and oral vitamin B12 depends on the cause and severity of deficiency plus patient preference

Yes, but separate applications

However, your diet is not the only factor determining vitamin B12 absorption

Sublingual vs intramuscular and oral routes of administration A previous systematic review by Cochrane compared the effectiveness of oral versus IM routes of vitamin B12 administration